Studies of rabbit MHC molecular have identified the complexity of rabbit leukocyte antigen (RLA) of class I, class II and class III genes as their DNA sequence are homologous to those of humans. The RLA class I genes is made up of 8 to 14 genes, depending on the haplotype. The class II genes are also very similar to the homologous genes of human HLA-DR, -DQ, -DP, and -DO genes. Many class III genes have been identified, including the TNF A and B genes. Learn more: Rabbit Leukocyte Antigen Typing

iPSCs (induced pluripotent stem cells) are a class of pluripotent stem cells that are derived from diverse somatic cell types. They have the capacity to differentiate into any type of cell in the body with high similarity to embryonic stem cells (ESCs). Given their easily accessible somatic cell origin and ability of robust proliferation and differentiation in vitro, iPSCs have been used for disease modeling, toxicity testing, drug screening, and transplantation therapies. Learn more: ips cells definition

In reality, small chemical compounds of 700-1500 Da are not appropriate immunogens. But, when attached to macromolecules, they usually become great immunogenic agents. These small molecules are referred to as a hapten and macromolecules conferring hapten immunogenic are referred to as a carrier. The hapten can be thought of as an exogenous epitope linked to the carrier. Learn more: TCs Hapten

Complement system plays an essential role in host defense. As a first-class leader in drug discovery, Creative Biolabs has applied advanced therapeutic antibodies development based on numerous complement components. Combining our advanced technologies and long-term scientific expertise, we can offer high-quality and custom services to meet our clients’ demands precisely. Now we have successfully developed a series of innovative and effective therapeutic antibodies for complement-associated diseases. Learn more: Drug Development for CD55

The Monkeypox Virus PCR Kit is a real-time PCR technique for detecting MPXV DNA in a liquid sample. The J2R gene, which is specific to the MPXV genome, is located using a fluorescent probe and specific primer sets. This product is furnished for research use only. Not for diagnostic or therapeutic use. Learn more: monkeypox pcr kit

As a world-leading service provider of antibody development and engineering, Creative Biolabs has combined artificial intelligence, big data, and machine learning to generate a novel artificial intelligence (AI)-powered computational antibody drug discovery platform to predict antibody-antigen binding and provide antibody drug candidates. Learn more: AI antibody discovery platform

Christensenella minuta is a recently described gastrointestinal bacterium that plays a significant role in the prevention of obesity. Here, Creative Biolabs provides a comprehensive range of high-quality services and support for the development of probiotics based on Christensenella minuta. Learn more: christensenella probiotic

Electrophysiology techniques provide a wealth of information regarding the molecular mechanisms that underlie the function and modulation of ion channels. Creative Biolabs is a contract research organization with over 10 years of expertise in our area of Neurological Electrophysiology expertise. We combine expertise, world-class facilities, and cutting-edge instrumentation to support companies involved in the research and development of products for neurological diseases.

Complement Factor H (CFH) is an essential regulator for normal complement activity, which negatively inhibits the alternative pathway and complement amplification. CFH is a large plasma protein encoded by the CFH gene.

Rapid identification of macrophages and their polarization states provides valuable information for drug discovery, toxicological screening, and immunotherapy evaluation. Equipped with a team of skilled scientists with an innovative Platform, which is designed specifically to meet very challenging requirements in macrophage development, Creative Biolabs offers fast, reliable support for our clients' macrophage marker development projects. Learn more: human macrophage markers

Creative Biolabs is looking for potential partners (include but not limit to major pharma or biotech firms) to develop anti-CD112 therapeutic monoclonal antibody program together. Our scientists are dedicated to bringing together years of valuable experience to our partner and achieve a meaningful partnership. By doing so, we wish to help both parties to proceed with IND and many stages of clinical trials beyond. Learn more: Next-IO™ Anti-CD112 Therapeutic Monoclonal Antibody Program

NeutAbs are part of the humoral response of the adaptive immune system to viruses, intracellular bacteria, and microbial toxins. They can not only bind to viruses, but also bind in a way that blocks infection. NeutAbs can protect cells from pathogens or infectious particles by neutralizing any of their biological effects. Learn more: Pseudovirus Neutralization Assay

The microfluidic chips hold promise for convenient integration and have the ability to integrate a Polymerase Chain Reaction (PCR) module to add a critical missing component to the lab-on-a-chip (LOC) toolkit. As a leader in microfluidic chips development, Creative Biolabs has rich experience and an efficient microfluidic technology platform to provide high-quality services related to microfluidic chip design and development for our global customers. Learn more: microfluidic dna purification

Creative Biolabs is experienced in the design and production of various kinds of multispecific and multifunctional immune checkpoint antibodies. The top research team of Creative Biolabs can make sure to put the necessary resources and solutions to provide customized, high-quality multispecific, and multifunctional antibody development services for our customers worldwide. Learn more: Multispecific Immune Checkpoint Antibody Development

Gentamicin is a broad-spectrum antibiotic originated from the fermentation of Micromonospora purpurea or echinospora. It is an antibiotic complex comprising three major components, gentamicin C1, C1a, C2, and a number of minor components. These major components have a difference in the degree of methylation in the 2-amino-hexose ring. Learn more: Haptens for Gentamicins Synthesis

Recombinant monoclonal antibody to CD25. Inolimomab is a mouse monoclonal antibody developed as an immunosuppressive drug against graft-versus-host disease. Its target is the alpha chain of the interleukin-2 receptor.

Natural killer (natural killer, NK) cells are lymphocytes of the innate immune system, which play an important role in preventing virus infection and inhibiting the development of cancer. NK cells account for 10%-15% of the total number of human peripheral blood lymphocytes. Because of the dense intracellular cytolytic granules expressed in the cells, they are also called large granular lymphocytes. Learn more: NK Cell-based Immunotherapy

Human induced pluripotent stem cells (iPSCs) derived from human somatic cells can differentiate into a variety of ocular cells such as corneal epithelial cells and retinal pigment epithelium cells. These cells provide effective tools for ophthalmologic disease modeling and personal drug development using stem cells as well as developing cell-based therapy. Learn more: stem cell in Ophthalmologic Diseases

The EPM2A gene, which encodes laforin, is mutated in an autosomal recessive form of adolescent progressive myoclonus epilepsy. The protein encoded by this gene binds to laforin, but its function is not known. This gene is intronless. Learn more: epm2aip1

Artificial intelligence (AI) technologies have also been widely used in antibody design based on big data and machine learning. In addition, the biophysical features of candidate antibodies, such as stability, solubility, chemical properties can be evaluated and optimized by different types of AI models to reduce the cost and improve the therapeutic efficiency.

AI can typically generate 10 times more antibody sequence clusters than a laboratory-based approach alone. Antibody diversity expanded by AI leads to the discovery of new binding modalities and potentially new therapeutic modes-of-action. Learn more: in silico antibody discovery